Methods

The following is a selection of our established methods; almost all of the methods can be carried out under GMP. We will be happy to offer you suitable validations or method transfers.

  • GC: Content and trace determinations using FID; residual solvents according to PhEur/USP; direct injection and headspace technology, chiral separations

  • HPLC: Content and trace determinations using UV-VIS, fluorescence and refractive index detectors; column temperatures up to 90°C, chiral separations, post column derivatization

  • IC: Analytic with anionic and cationic columns, separation of minor anions up to major API cations

  • Methods according to PhEur and USP (as well as PhHelv, DAB, JP, BP, ÖAB. . .) under GMP, such as for example:
    full analyses under complete monographs, content determinations using GC/HPLC/titration/...,
    determination of impurities, migration studies (for example, on plastic and glass containers, adhesive labels, . . . ), thin-layer chromatography (qualitative and semi-quantitative), limit testing, microbiological germ-count determinations, microbiological content determination of antibiotics (inhibiting areola and turbidimetric), preservative stress test, test for endotoxins (LAL test), determination of nitrogen and protein content acc. to Kjeldahl, capillary viscosity (Ubbelohde), rotation viscosity (Brookfield), disintegration time of capsules and tablets, dissolution studies, pill hardness, dropping point, melting point, boiling point, freezing point, heavy metals according to PhEur 2.4.8 / USP <231>, chromatographic profile, colour and turbidity, spreadability, consistency (penetrometer), water according to Karl-Fischer (volumetric and coulometric), residual solvents, fatty acid spectrums, sterols using TLC/GC, fat ratios, sieve analyses (from 1000 to 25 µm), osmolality and much more.

  • Food analytics according to DIN/EN, SLMB and our own methods, such as:
    vitamins, ethanol content, fatty acid spectrums, microbiological quality, content determinations, carbohydrates, fat, protein, dry matter, salt content, sweeteners, cholesterol, fat ratios, free fatty acids, starch, organic acids, BHT, preservatives, caffeine, theobromine, thujone, . . .

  • THC analytics in cannabis, food and pharmaceutical products – in accordance with our special license from BAG
    Δ9-THC content, THC-CBD ratio, various THC derivatives determination

  • Steroid analytics in tablets, powders, water or oily solutions
    We have the methods and experience to find over 60 different steroids, and our repertoire is constantly being expanded.